Services
We offer services to dental clinics in the field of genetics and microbiology.
Precision implantology: diagnosis for the prevention of peri-implant complications
Implantology has revolutionized restorative dentistry. However, the long-term success of implants can be compromised by multiple factors. One of the most relevant is peri-implantitis, a progressive inflammation of peri-implant tissues caused by the interaction between the bacterial biofilm and an exacerbated host inflammatory response. At Hyssogenix, we offer comprehensive diagnostics to evaluate the biological risk of implant failure prior to implant placement.
Precision implantology: diagnosis for the prevention of peri-implant complications
Implantology has revolutionized restorative dentistry. However, the long-term success of implants can be compromised by multiple factors. One of the most relevant is peri-implantitis, a progressive inflammation of peri-implant tissues caused by the interaction between the bacterial biofilm and an exacerbated host inflammatory response. At Hyssogenix, we offer comprehensive diagnostics to evaluate the biological risk of implant failure prior to implant placement.
Implant failure can be due to different causes depending on the stage:
- Early failures: related to problems with osseointegration, bone overheating, micromovements, or postoperative infection.
- Late failures: frequently associated with peri-implantitis, caused by periodontopathogenic bacteria and modulated by genetic, mechanical, and prosthetic factors.
👉 Assessing both the bacterial load and the genetic inflammatory response makes it possible to anticipate these risks and adapt the implantology protocol.
Using qRT-PCR, we detect peri-implant bacteria highly associated with complications:
- Porphyromonas gingivalis
- Treponema denticola
- Tannerella forsythia
- Aggregatibacter Actinomycetemcomitans
- Prevotella intermedia
- Staphylococcus aureus
🔬 Detection of Staphylococcus aureus is particularly important due to its antimicrobial resistance and ability to form biofilm on implants, making it critical in the prophylaxis and management of infectious complications.
We evaluate the presence of genetic variants associated with excessive inflammatory response:
- IL1 alpha
- IL1 beta
- GLT6D1
- CDKN2B
These variants are involved in the overproduction of proinflammatory cytokines, increasing the risk of peri-implant inflammation even in the presence of low bacterial load.
- Decide on pretreatments in patients with high microbial load.
- Plan more frequent follow-ups in patients with genetic predisposition.
- Personalize long-term maintenance protocols.
- Improve patient acceptance and compliance by presenting objective data.
- Results in less than 72 hours
- High sensitivity and specificity
- Early identification of biological risk factors
- Non-invasive sampling (paper points in the subgingival area)
📦 Provide your patients with predictive implant treatment supported by clinical and genetic evidence.
Is this analysis performed before or after implant placement?
Ideally before, to assess bacterial and genetic risk and prevent peri-implantitis. The analysis can also be used after implant placement when complications (mucositis, peri-implantitis, abscesses) have arisen, to treat them in a specific and effective way.
Which bacteria are detected in the test?
Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Aggregatibacter Actinomycetemcomitans, Prevotella intermedia, Staphylococcus aureus.
Which genes are analyzed in the genetic profile?
IL1 alpha, IL1 beta, GLT6D1, CDKN2B, implicated in excessive inflammation against biofilm.
How is the sample collected?
Using paper points in the subgingival area, painlessly in the clinic.
How long do the results take?
Less than 72 hours from sample reception at the laboratory.
What clinical advantages does this analysis provide?
It allows anticipation of complications, personalization of treatment planning, and increased implant success.
More precise treatments for your clients
Improve the effectiveness of your practice
