Services
We offer services to dental clinics in the field of genetics and microbiology.
Molecular and genetic diagnosis for personalized prevention of periodontal disease
Periodontitis is an inflammatory disease of bacterial origin that affects the supporting dental tissues. It begins as gingivitis—a superficial inflammation of the gums—but if left untreated, it can progress to compromise the periodontal ligament and alveolar bone, leading to loss of attachment, tooth mobility, and even tooth loss.
Molecular and genetic diagnosis for personalized prevention of periodontal disease
Periodontitis is an inflammatory disease of bacterial origin that affects the supporting dental tissues. It begins as gingivitis—a superficial inflammation of the gums—but if left untreated, it can progress to compromise the periodontal ligament and alveolar bone, leading to loss of attachment, tooth mobility, and even tooth loss.
Its course varies among patients. There are two main clinical forms, with different presentation, age of onset, and progression speed:
- Chronic periodontitis: appears from the age of 30, with slow and progressive advancement. It is associated with persistent inflammation, poor oral hygiene, smoking, and genetic factors.
- Aggressive periodontitis: occurs in young individuals and progresses rapidly, even with low bacterial load, due to an exaggerated inflammatory response of genetic origin.
👉 Although lifestyle factors play a role, the key difference between patients lies in the combination of pathogenic bacteria and genetic susceptibility.
At Hyssogenix we use a comprehensive approach to periodontal diagnosis through microbiota and patient genetic analysis. Using qRT-PCR, we quantify five key bacteria in the development of the disease:
- Very high risk:
- Porphyromonas gingivalis
- Aggregatibacter actinomycetemcomitans
- High risk:
- Treponema denticola
- Tannerella forsythia
- Prevotella intermedia
This profile allows for the design of a personalized treatment plan and helps determine whether antibiotics are needed beyond conventional mechanical therapy.
Clinical advantages of PCR analysis
- Results in < 72 hours
- High sensitivity (>95%)
- Targeted antibiotic selection
- Prevention of unnecessary empirical antibiotic therapy
💡 These bacteria have also been linked to systemic diseases such as Alzheimer’s, cardiovascular disease, type II diabetes, and preterm birth.
This test analyzes genetic variants that influence the severity and progression of the disease:
- Aggressive periodontitis: GLT6D1, CDKN2B
- Chronic periodontitis: IL1 alpha, IL1 beta
Advantages of genetic analysis
- Needs to be performed only once in a lifetime
- Determines genetic risk
Improves planning of follow-ups and patient adherence
Thanks to the combination of bacterial and genetic results, the dentist can:
- Prevent the onset of disease in high-risk patients
- Detect aggressive forms before they manifest clinically
- Adapt treatment with greater precision
- Build patient loyalty through personalized follow-up based on objective data
📦 Request your sampling kit and apply personalized dentistry in your practice.
Does this test replace periodontal probing?
No. It is an advanced complement that provides microbiological and genetic information that probing cannot detect.
Which bacteria does the test analyze?
Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola, Tannerella forsythia, and Prevotella intermedia.
How long do the results take?
Less than 72 hours after sample reception at the laboratory.
What is the utility of the genetic analysis?
It determines whether the patient has a predisposition to develop severe or early-onset periodontitis.
How often should the test be repeated?
The genetic test only once in a lifetime. The microbiological test can be repeated after treatment or during follow-ups.
Does it help decide whether to use antibiotics?
Yes. The bacterial profile guides the choice of the most appropriate antibiotic and avoids unnecessary use.
More precise treatments for your clients
Improve the effectiveness of your practice
