The randomised, double-blind, placebo-controlled clinical trial investigated the therapeutic potential of the probiotic Streptococcus dentisani (strain 7746) in the promotion of oral health, with particular focus on the prevention of dental caries. Through topical application of a bucoadhesive gel containing S. dentisani, a number of clinical and microbiological parameters were evaluated in 59 participants over a one-month treatment period.
The results revealed significant improvements in multiple aspects of oral health in the S. dentisani-treated group compared to the placebo group. A marked decrease in dental plaque accumulation and gingival inflammation was observed, suggesting a positive effect on reducing the risk of diseases such as caries and periodontitis. This finding is of particular importance, given that both diseases are closely related to the formation of microbial biofilms in the oral cavity.
In addition, there was a significant increase in the flow of saliva in the probiotic-treated group from the early stages of the study. This increased flow, together with high levels of calcium and ammonium in the saliva of participants treated with S. dentisani, could contribute to dental remineralisation and provide better oral pH buffering capacity, creating an environment less prone to the development of caries.
Microbiological analyses revealed favourable changes in the composition of the oral microbiota after treatment with S. dentisani. A lower presence of organisms that are known to play a role in the formation of cariogenic biofilms was observed, suggesting a shift towards a more balanced and healthier oral microbiota.
Despite these encouraging results, the need to optimise treatment efficacy through more effective colonisation of S. dentisani in the oral cavity was highlighted. This suggests the importance of future research aimed at improving the dosage, application method and formulation of the probiotic to maximise its oral health benefits.
In summary, the study supports the feasibility of using S. dentisani as a promising oral probiotic for the prevention of dental caries and the promotion of oral health in general. Further studies are needed, however, to better understand the underlying mechanisms that act and to optimise the effectiveness of this therapeutic approach.
